GO:0070765 cellular_component gamma-secretase complex
| PAG Title | GO:0070765 cellular_component gamma-secretase complex |
| PAG ID | TAX029104 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the amyloid-beta precursor protein. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,032 |
| Information Content | Rich |
| Other IDs | GO:0070765 |
| Base PAG ID | TAX029104 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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